Multimarker prediction of coronary heart disease risk: the Women's Health Initiative.

Using Combined Descriptive and Predictive Methods of Data Mining for Coronary Artery Disease Prediction: a Case Study Approach

Heart disease is one of the major causes of morbidity in the world. Currently, large proportions of healthcare data are not processed properly, thus, failing to be effectively used for decision making purposes. The risk of heart disease may be predicted via investigation of heart disease risk factors coupled with data mining knowledge. This paper presents a model developed using combined descri...

Electrocardiographic abnormalities that predict coronary heart disease events and mortality in postmenopausal women: the Women's Health Initiative.

BACKGROUND Information is limited about the independent prognostic value of repolarization abnormalities in women. METHODS AND RESULTS We evaluated hazard ratios for ECG variables for combined fatal and nonfatal coronary heart disease (CHD) events and for CHD mortality using Cox regression in 38,283 Women's Health Initiative (WHI) participants during up to 9.2 years of follow-up. All risk mod...

The women's health initiative reports in perspective: facts or fallacies?

There are no new data in the Women's Health Initiative. The Collaborative Study of Hormone Factors in breast cancer showed a non-significant increased risk after 5 years. HERS showed an increased risk of cardiovascular disease in HT users with previous heart disease. The Cache County study indicated that estrogen therapy initiated after age 60 increased the incidence of Alzheimer's disease. The...

Clinical Utility of Multimarker Genetic Risk Scores for Prediction of Incident Coronary Heart Disease

Hormone replacement therapy and risk of cardiovascular disease: implications of the results of the Women's Health Initiative.

The higher rates of coronary heart disease (CHD), stroke, and venous thrombosis among women taking estrogen and progesterone (E+P) compared with placebo in the Women's Health Initiative clinical trial have important implications for women's health. Previous studies in both men and women have shown that estrogen therapy lowers low-density lipoprotein cholesterol and raises high-density lipoprote...